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This means that while the association is clear and the mechanisms are well-hypothesized, definitive answers about causation, dose-response relationships, and optimal prevention remain areas of active investigation

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To achieve this goal, a combination of a bleeding score with a platelet threshold defined by a platelet count less than or greater than 30 × 10³/µL is considered a practical approach that clinically distinguishes between “NR” and “R” patients 10,47